THC and placebo groups were comparable at baseline. Compared with placebo, THC-treated patients reported improved and enhanced chemosensory perception and food 'tasted better'. Premeal appetite and proportion of calories consumed as protein increased compared with placebo. THC-treated patients reported increased quality of sleep and relaxation. Quality of life scores and total caloric intake increased lead to the conclusion that THC may be useful in the palliation of chemosensory alterations and to improve food enjoyment for cancer patients.