This review of 1217 abstracts culminated in a deep dive on 39 scholarly articles to review the effetcs of individual cannabinoids and combinations of cannabinoids as analgestics (used for pain management). This is a great opportunity to broadly review 39 peer qualified articles on the efficacy of cannabis as a pain management solution and begin to understand the limitations which of researching this complex therapeutic agent. It organizes the culminated findings by "Healthy Control Samples (3.1)" (subjects without underlying medical conditions) and "Patient Samples (3.2)" (subjects with underlying conditions).
This study led to the conclusion that high CBD to CBN ratios have a significant effect on reducing muscle withdrawal response (speeds relaxation) without impairing motor function. This essentially means that a high CBD:CBN ratio dose promotes muscular relaxation and inhibits the pain response to stress but does not impair the patient.
These results suggest that peripheral application of these non-psychoactive cannabinoids may provide analgesic (pin) relief for chronic muscle pain disorders such as temporomandibular disorders and fibromyalgia without central side effects.